Osmoregulation of aldose reductase and sorbitol dehydrogenase in cultivated interstitial cells of rat renal inner medulla
نویسندگان
چکیده
منابع مشابه
Aldose reductase and myo-inositol transporter mRNA are independently regulated in rat renal medulla.
During antidiuresis, renal papillary cells accumulate organic osmolytes preferentially over inorganic ions. It has been previously demonstrated that sodium infusion increased all of these organic osmolytes except myo-inositol (1). Conversely, urea infusion increased only glycerophosphorylcholine significantly. In addition to sodium and urea, potassium localized in tissue and urine influenced th...
متن کاملImmunomorphometric study of rat renal inner medulla.
We utilized immunofluorescent immunolabeling of renal tissue sections to identify and count tubules at specified depths of the rat renal inner medulla. We used primary antibodies to aquaporin-1 (AQP1; labeling thin descending limbs), aquaporin-2 (AQP2; labeling inner medullary collecting ducts), the rat kidney-specific chloride channel (ClC-K1; labeling thin ascending limbs), and von Willebrand...
متن کاملThe sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.
The sorbitol pathway in human lenses is evaluated on the enzymic level. Adult lenses, normal and nondiabetic as well as diabetic cataracts, are found to contain limited levels of aldose reductase (AR) and high levels of polyol dehydrogenase (PD) relative to the animal lens. AR is confined primarily to the lens epithelium and is two to three times higher in juvenile lenses than in the adult lens...
متن کاملInhibition of aldose reductase and sorbitol accumulation by dietary rutin
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2 or AKR1B1) activity has been implicated in the development of various secondary complications of diabetes. Previously we have reported that some common dietary sources such as spices, fruits and vegetables have the potential to inhibit ALR2 under in vitro conditions and in animal models. In this study, we describe th...
متن کاملErythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
PURPOSE Activation of polyol pathway due to increased aldose reductase (ALR2) activity has been implicated in the development of diabetic complications including diabetic retinopathy (DR), a leading cause of blindness. However, the relationship between hyperglycemia-induced activation of polyol pathway in retina and DR is still uncertain. We investigated the relationship between ALR2 levels and...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2003
ISSN: 1460-2385
DOI: 10.1093/ndt/gfg397